Both locations of Deano's have great hamburgers and cheeseburgers. Southside Bakery on W. Congress are also good.
I was never too keen on them. Kind of 'meh' to me.
I've tried both the 'original' there on Johnston and the ones that're part of the chain - very different menus. Both of them are kinda unimpressive. Good burgers, don't get me wrong, I'll be happy to eat there, but for the "woohoo" of burgers I just don't think so.
Then again, I tried thinking about where a real good burger would be in Lafayette and I can't recall where I've gotten a damned fine burger - I tend to just make my own at home when I want something specific and awesome.